Faculty and Research
The Neuroscience training faculty are excellent and well-supported researchers and teachers. The group includes recipients of the National Institutes of Health Javits Awards for excellence in neuroscience, NIH Merit and Career Development Awardees, and Alfred P. Sloan Foundation Fellows.
The training faculty are selected from four basic science and five clinical departments, Biochemistry/Biophysics/Genetics, Cellular and Developmental Biology, Pharmacology, Physiology, Radiology, Medicine, Neurology, and Psychiatry, carrying out their research in close collaboration with their graduate students and postdoctoral associates.
The Neuroscience faculty constitute a good balance of tenured and junior professors.Research Areas
The Neuroscience Training Program at the University of Colorado provides multidisciplinary training covering the breadth of neurobiology, from neuronal gene regulation to the development, structure, and function of the nervous system. Students receive training in cellular and molecular neurobiology, neural development, neuropharmacology, and biochemistry, as well as hands-on training in a variety of state-of-the-art laboratory techniques.
The tremendous advances in molecular biology during the past few decades have greatly enhanced research in the neurosciences. Specific macromolecules important in neuronal function have been identified and characterized with increasing frequency. The mechanisms by which these molecules act, and the cellular controls over their genetic expression have begun to be elucidated. Our studies are concerned with all of these aspects of molecular neuroscience.
The brain shows a higher complexity in its RNA when compared to other organs. More unique sequence single copy DNA is transcribed and found associated with polysomes in brain than in any other tissue. The functional significance of this complexity is unknown. Many of these mRNAs occur less than one copy per every ten cells, suggesting a high degree of cellular specificity in neural gene expression. How neural gene expression is regulated is an area of active interest among our faculty.
In part neural genes are regulated in response to specific growth factors (e.g., nerve growth factor), hormones, and neurotransmitters. Although some of these molecules act by binding to cytoplasmic receptors, many of them act by binding to specific cell surface receptors, some of which are subsequently internalized as a complex, while others act by transmembrane signalling of their binding via membrane proteins coupled to GTP binding proteins or polyphosphoinositide--diacylglycerol generation. These signalling systems act to alter the activity of intracellular protein kinases, which act to influence gene transcription, ion channels, and neurotransmitter release and reception. The interaction of neurotransmitters and growth factors with their receptors, signal transduction mechanisms and the role of protein phosporylation in the function of specific neural proteins are a major focus of our research.
Recombinant DNA technology and gene cloning procedures are used routinely in many of these studies. The availability of a mouse brain genomic library and expression systems puts essentially every gene of interest within reach, and permits an analysis of gene expression and functional aspects of the gene product.
The brain shows a higher complexity in its RNA when compared to other organs. More unique sequence single copy DNA is transcribed and found associated with polysomes in brain than in any other tissue. The functional significance of this complexity is unknown. Many of these mRNAs occur less than one copy per every ten cells, suggesting a high degree of cellular specificity in neural gene expression. How neural gene expression is regulated is an area of active interest among our faculty.
In part neural genes are regulated in response to specific growth factors (e.g., nerve growth factor), hormones, and neurotransmitters. Although some of these molecules act by binding to cytoplasmic receptors, many of them act by binding to specific cell surface receptors, some of which are subsequently internalized as a complex, while others act by transmembrane signalling of their binding via membrane proteins coupled to GTP binding proteins or polyphosphoinositide--diacylglycerol generation. These signalling systems act to alter the activity of intracellular protein kinases, which act to influence gene transcription, ion channels, and neurotransmitter release and reception. The interaction of neurotransmitters and growth factors with their receptors, signal transduction mechanisms and the role of protein phosporylation in the function of specific neural proteins are a major focus of our research.
Recombinant DNA technology and gene cloning procedures are used routinely in many of these studies. The availability of a mouse brain genomic library and expression systems puts essentially every gene of interest within reach, and permits an analysis of gene expression and functional aspects of the gene product.
Cells of the nervous system are some of the most unique cells found in organisms. Many of these cells have evolved sophisticated structures and mechanisms to sense the slightest differences in light, color, sound, taste, smell, touch, etc. The neurons which transmit this information are not only unique cells but are among the most highly specialized of all cells, both structurally and functionally. Long threadlike processes (axons and dendrites) may stretch a meter or more from the cells nucleus, making highly specific synaptic connections with other cells. Functionally these neurons respond by sending electrical signals in the form of action potentials brought about by the opening and closing of specific ion channels. The action potential is rapidly and efficiently transmitted along these delicate processes. At the axon terminus special chemicals (neurotransmitters) are synthesized, packaged and, upon arrival of an action potential, secreted into the synaptic cleft. The secreted neurotransmitters bind to specific receptors on adjacent neurons and modify their electrical and metabolic activity.
The basic mechanisms of these numerous and different ion channels that are responsible for the unique properties of neurons are being actively pursued by our faculty. They are using a variety of biochemical, pharmacological and electrophysiological techniques including patch clamp recording of single ion channels. Neurotransmitter receptors are being localized and quantified in neural tissue using radiolabelled ligands and computer based image processing of autoradiographs. Other faculty are characterizing these sensory cells and their connecting pathways in the CNS with modern electron microscopic, elctrophysiological and immunochemical procedures.
The basic mechanisms of these numerous and different ion channels that are responsible for the unique properties of neurons are being actively pursued by our faculty. They are using a variety of biochemical, pharmacological and electrophysiological techniques including patch clamp recording of single ion channels. Neurotransmitter receptors are being localized and quantified in neural tissue using radiolabelled ligands and computer based image processing of autoradiographs. Other faculty are characterizing these sensory cells and their connecting pathways in the CNS with modern electron microscopic, elctrophysiological and immunochemical procedures.
The development of the brain is one of the most complex phenomena in biology. A dynamic interplay between genetic and environmental cues guides the proliferation, migration and differentiation of neurons and glial cells, as well as the outgrowth of axons and their guidance to and recognition of appropriate target cells. From studies of specific molecules to expression of emergent behavior, our faculty are actively involved in developmental neuroscience.
At early times in neural development, proliferating neuroblasts cease dividing in response to yet unknown signals. They then begin to express differentiated properties including axonal outgrowth, and most undergo cell migration. Axon formation is initiated by the post-mitotic neuron and usually proceeds in the direction necessary to reach its appropriate target. The axonal growth cone is the dynamic motile structure that searches out the target. Externally the growth cone possesses neural cell adhesion molecules and other cell recognition molecules that interact with cellular and extracellular molecules to guide the axon toward its synaptic target. Developing and regenerating axonal growth cones possess unique molecules, including a growth associated protein, as well as the ability to secrete proteases such as plasminogen activator; the roles these specific neuronal molecules play in development are areas of active interest among our faculty.
Similarly, the cell recognition mechanisms associated with axonal pathfinding, synaptogenesis, and the molecular and physiological mechanisms for the stabilization of these synapses, as well as the elimination of multiple synapses are major areas of faculty research.
At early times in neural development, proliferating neuroblasts cease dividing in response to yet unknown signals. They then begin to express differentiated properties including axonal outgrowth, and most undergo cell migration. Axon formation is initiated by the post-mitotic neuron and usually proceeds in the direction necessary to reach its appropriate target. The axonal growth cone is the dynamic motile structure that searches out the target. Externally the growth cone possesses neural cell adhesion molecules and other cell recognition molecules that interact with cellular and extracellular molecules to guide the axon toward its synaptic target. Developing and regenerating axonal growth cones possess unique molecules, including a growth associated protein, as well as the ability to secrete proteases such as plasminogen activator; the roles these specific neuronal molecules play in development are areas of active interest among our faculty.
Similarly, the cell recognition mechanisms associated with axonal pathfinding, synaptogenesis, and the molecular and physiological mechanisms for the stabilization of these synapses, as well as the elimination of multiple synapses are major areas of faculty research.
Some of the most obvious, interesting and widespread aspects of behavioral neuroscience are those associated with particular disease states. Especially notable are the movement defects that affect tens of thousands of individuals with Parkinsons disease, and the memory loss and confusion associated with Alzheimers disease in many senior citizens. Both of these disorders reflect the loss of specific cell populations in the substantia nigra and basal forebrain, respectively.
One of the most recent and exciting approaches to the treatment of these disorders is the use of nerve cell transplants. Our faculty have been pioneers in the field of intraocular and brain transplants. Currently they are actively pursuing the use of fetal brain tissue grafts in animal models, to gain a better understanding of the requirements for graft survival and their interaction with host tissues to restore functional behavior in these brain regions.
Other faculty are studying the action of various behavior altering drugs on specific neurons and their electrical and synaptic activity. Their development of miniaturized electrochemical electrodes for monitoring neurotransmitter release in specific brain regions has greatly enhanced such analysis. The biological action of various neuropeptides, specifically those related to pain, are being characterized at the molecular level using modified synthetic peptides in animal models.
One of the most recent and exciting approaches to the treatment of these disorders is the use of nerve cell transplants. Our faculty have been pioneers in the field of intraocular and brain transplants. Currently they are actively pursuing the use of fetal brain tissue grafts in animal models, to gain a better understanding of the requirements for graft survival and their interaction with host tissues to restore functional behavior in these brain regions.
Other faculty are studying the action of various behavior altering drugs on specific neurons and their electrical and synaptic activity. Their development of miniaturized electrochemical electrodes for monitoring neurotransmitter release in specific brain regions has greatly enhanced such analysis. The biological action of various neuropeptides, specifically those related to pain, are being characterized at the molecular level using modified synthetic peptides in animal models.
Faculty and Research Specializations
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Mazen Al Borno PhD
Assistant Professor
Research Focus:
Motor and Cognitive Disorders
Without being conscious of it, our motor system is constantly solving computationally challenging problems in ways that astonish both roboticists and neuroscientists. We develop computational models of animal movement to understand how the brain generates movement and design novel rehabilitation therapies and assistive devices for patients with movement disorders. We collaborate closely with neuroscientists, clinicians and roboticists to study the brain and help patients achieve a better quality of life.
Allyson Alexander MD, PhD
Assistant Professor
Research Focus:
Epilepsy
I study basic mechanisms of how epilepsy develops using human and mouse models.
Jason Aoto PhD
Associate Professor;
Director, Pharmacology Program
Research Focus:
Accepting Students
Drugs of Abuse
Neuropharmacology
Optogenetics
Psychiatric Disorders & Functional Imaging
Signal Transduction
Synaptic Signaling and Plasticity
We employ cutting-edge approaches including mouse genetics, optogenetics, viral circuit tracing, ex vivo slice electrophysiology, CRISPR/cas9 genome editing, single-cell RNA-sequencing and super-resolution microscopy to investigate how disease-relevant synaptic molecules are utilized in a cell-type- and synapse-specific manner in neural circuits implicated in neuropsychiatric disorders and addiction.
Bruce Appel PhD
Professor
Research Focus:
Development
Developmental Biology
Developmental Neuroscience
We investigate the genetic, molecular and cellular basis of brain development and myelination using zebrafish as a model system.
Tracy Bale PhD
Professor
Research Focus:
Developmental Neuroscience
Developing mouse models of stress sensitivity using genetic and prenatal manipulations to understand the mechanism and heritability for increased susceptibility to neurodevelopmental disorders. Examine the effects of maternal and paternal stress on fetal development and long-term physiological and behavioral responses.
John Bankston PhD
(He/Him/His)
Associate Professor
Research Focus:
Cardiovascular & Pulmonary Biology
Cellular Physiology
Ion Channels & Biophysics
Macromolecular Structure
Neuropharmacology
Signal Transduction
We are interested in the molecular mechanisms of cellular excitability in the heart and brain. Our focus is on two different families of ion channels, the acid-sensing ion channels (ASICs) and hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels. We study the structural and physiological mechanisms of channel function for each class of channel including how these channels are regulated by other proteins as well as the lipid membrane. To do this we use a combination of patch clamp, FRET, single-molecule fluorescence, and biochemistry.
Linda Barlow PhD
Professor
Research Focus:
Accepting Students
Development
Developmental Neuroscience
Sensory Systems
Stem Cells
We use in vivo molecular genetic mouse models, and in vitro taste organoids derived from adult lingual stem cells to understand how taste buds renew during normal homeostasis, and how this regenerative process is impacted by cancer therapies that cause taste dysfunction in patients.
Emily Bates PhD
(She/Her/Hers)
Associate Professor
Research Focus:
Accepting Students
Developmental Biology
Developmental Neuroscience
Fly Research Group
Genomics Bioinformatics
Motor and Cognitive Disorders
Neuropharmacology
Other Developmental Disorders
We study how ion channel activity (bioelectricity) contributes to morphological development in multiple tissues (craniofacial structures, fly wings, brain, pancreas, and bone).
Ulli Bayer PhD
Professor
Research Focus:
Accepting Students
Down Syndrome & Alzheimer's
Ion Channels & Biophysics
Motor and Cognitive Disorders
Neurobiology of Stroke
Neuropharmacology
Signal Transduction
Structural Biology
Synaptic Signaling and Plasticity
Our field is molecular and cellular neuroscience. Specifically, we are interested in the molecular and cellular mechanisms underlying learning, memory and cognition. We also want to know how these mechanisms go wrong in disease, and how this could be repaired by new therapeutic strategies.
Kurt Beam PhD
Distinguished Professor
Research Focus:
Ion Channels & Biophysics
My lab investigates intracellular calcium signals, which play essential roles including the activity-dependent regulation of gene expression in diverse cell types, muscle contraction, and neuronal plasticity. We use a variety of techniques including molecular biology, electrophysiology, biochemistry, and analysis of structure.
Email:kurt.beam@cuanschutz.edu
Timothy Benke MD, PhD
Professor
Research Focus:
Accepting Students
Developmental Neuroscience
Epilepsy
Ion Channels & Biophysics
Neuropharmacology
Other Developmental Disorders
Synaptic Signaling and Plasticity
My laboratory studies the function of synapses, the primary means of communication between neurons in the brain. Discoveries include mechanisms for synaptic changes that are likely associated with learning and memory. Research is directed at discovering how synapses change with development and following seizures. Our results are specifically directed to help prevent and treat the effects of early-life seizures (ELS), which can include autism, learning impairment and epilepsy.
Email:tim.benke@cuanschutz.edu
Jeffrey Bennett MD, PhD
Professor
Research Focus:
Neuroimmunology
My research focuses on antigen identification in optic neuritis, multiple sclerosis, neuromyelitis optica, and ocular inflammatory disorders.
Kimberley Bruce PhD
Associate Professor
Research Focus:
Down Syndrome & Alzheimer's
Neuroendocrinology
Neuropharmacology
Many neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease (AD) are more prevalent in women and have a marked impact on physical and mental health. Female sex is a major risk factor for late-onset AD, and females carrying the APOE4 gene are more likely to develop severe AD. Despite these well-known associations, the reason for this increased risk is unclear. Recent work from Dr. Bruce's laboratory has shown that females have enhanced fat and cholesterol metabolism in specialized brain cells, which may be detrimental in the presence of AD risk factors such as APOE4.
Joseph Brzezinski PhD
Associate Professor
Research Focus:
Accepting Students
Development
Developmental Neuroscience
Sensory Systems
We are interested in uncovering the mechanisms that regulate mammalian retinal development and applying this knowledge to inform novel stem cell based treatments that restore vision. We primarily use the mouse as a model system, as its development is similar to human, and because there is a wealth of genetic resources we can utilize.
John Caldwell PhD
Professor
Research Focus:
Cell Biology
Ion Channels & Biophysics
Neuroengineering
Optogenetics
Alzheimer’s Disease is associated with plaques of beta amyloid protein in the brain. Beta amyloid is a cleavage product of the amyloid precursor protein (APP). The structure of APP suggests that it acts as an adhesion molecule and/or a signaling receptor, but the normal function of this protein remains unknown. APP is located at synapses in the central and peripheral nervous systems. We are using transgenic mice that express truncated APP to study the role of APP in establishing and maintaining the structure and function of the neuromuscular synapse.
Jason Christie PhD
Professor
Research Focus:
Accepting Students
Ion Channels & Biophysics
Motor and Cognitive Disorders
Neuropharmacology
Optogenetics
Other Systems
Synaptic Signaling and Plasticity
The Christie Lab endeavors to understand the neural-circuit-mechanisms that underlie the learning-dependent optimization of behavior. The lab’s approach mainly focuses on the cerebellum, a brain region that guides adaptive updating of simple reflexive movements as well as experience-driven refinement of high-order brain function (e.g., thinking, planning, and decision making).
Fabrice Dabertrand PhD
Associate Professor
Research Focus:
Accepting Students
Cardiovascular & Pulmonary Biology
Ion Channels & Biophysics
Neurobiology of Stroke
Neuropharmacology
Psychiatric Disorders & Functional Imaging
Signal Transduction
The control of cerebral blood flow by ion channels and calcium signaling in the pericytes, endothelial cells, and smooth muscle cells that constitute the parenchymal microcirculation, and use this information to combat brain diseases with a vascular component.
Mark Dell'Acqua PhD
Professor
Research Focus:
Accepting Students
Down Syndrome & Alzheimer's
Ion Channels & Biophysics
Motor and Cognitive Disorders
Neuropharmacology
Signal Transduction
Synaptic Signaling and Plasticity
My laboratory’s specific research in the area of neuropharmacology focuses on understanding how cAMP and calcium second messenger signaling pathways are organized at the postsynaptic specializations of excitatory neuronal synapses.
Daniel Denman PhD
(He/Him)
Assistant Professor
Research Focus:
Accepting Students
Neuroengineering
Optogenetics
Sensory Systems
We are interested in how populations of neurons generate sensory perceptions. We use quantitative psychophysics, in vivo electrophysiology and neurostimulation, in vivo imaging, circuit tracing, optogenetics, and computational methods to study and manipulate the dynamics of populations of single neurons. We are also focused on how neural interactions specifically - within areas and distributed across the brain - generate successful perceptions.
Caroline Dias MD, PhD
Assistant Professor
Research Focus:
Neurodevelopment
Neurogenetics
The Dias Lab is broadly interested in the genetic basis of human brain function. We are interested in better understanding the molecular mechanisms underlying the healthy human brain as well as neurodevelopmental, psychiatric, and neurodegenerative disorders. In order to do this, we are tackling two major challenges in the field- cellular and clinical heterogeneity.
Robert Dietz MD, PhD
Assistant Professor
Research Focus:
Accepting Students
Neurobiology of Stroke
Neuropharmacology
Strategies for restoration of synaptic plasticity following cerebral ischemia.
David DiGregorio PhD
Professor and Chair
Research Focus:
Accepting Students
Motor and Cognitive Disorders
Neuropharmacology
Signal Transduction
Synaptic Signaling and Plasticity
The DiGregorio laboratory studies the role of synaptic and neuronal mechanisms influencing how the brain represents time for executing precise behaviors. Projects in the lab span multiple scales (from molecules to circuits to behavior) but also across multiple disciplines (cellular and molecular neurobiology to theoretical neuroscience).
Gidon Felsen PhD
(He/Him)
Professor
Research Focus:
Accepting Students
Cellular Physiology
Molecular Nutrition & Metabolic Systems
Motor and Cognitive Disorders
Neuroengineering
Optogenetics
Other Systems
The Felsen lab studies the neural circuit basis of behavior and decision making. We use electrophysiological, behavioral, pharmacological, molecular, and computational methods to examine how sensory input is transformed into plans for motor output, and how movements in turn affect sensory perception and representations. We are interested in how these processes occur in the normal brain, as well as how they are affected by pathological conditions.
Thomas Finger PhD
Professor
Research Focus:
Developmental Neuroscience
Other Systems
Sensory Systems
A major emphasis in my laboratory is on questions concerning the development and organization of these systems in several vertebrate models. Three major areas are under investigation at present: 1) morphology and function of solitary chemosensory cells (see Finger et al. PNAS 2003) in protection of the airways and gut, 2) the cellular organization and development of taste buds (see Finger et al, Science 2005, and 3) regulation of feeding behavior by taste and other oropharyngeal chemoreceptors.
Christopher Ford PhD
Professor
Research Focus:
Accepting Students
Drugs of Abuse
Ion Channels & Biophysics
Motor and Cognitive Disorders
Neuropharmacology
Optogenetics
Psychiatric Disorders & Functional Imaging
Signal Transduction
Synaptic Signaling and Plasticity
Our lab examines how neuromodulators are encoded in the mesolimbic and nigrostriatal systems and how circuit dysfunctions in these areas contribute to neurological and psychiatric disorders.
Santos Franco PhD
Associate Professor
Research Focus:
Development
Developmental Neuroscience
The cerebral cortex is the control center of most of our higher-level brain functions, including thought, language, memory and emotion. During cortical development, billions of neurons and glia must be precisely specified and assembled into the intricate circuits that underlie these complex tasks. Disruption of these processes is associated with many devastating human neurological disorders, including epilepsy, schizophrenia, autism and intellectual disability. Our lab studies several processes involved in the formation and function of neural circuits in the cerebral cortex.
Emily Gibson PhD
Associate Professor
Research Focus:
Cellular Physiology
Neuroengineering
Optogenetics
Professor Gibson's lab conducts multidisciplinary research at the intersection of photonics and neuroscience. Our lab develops novel optical devices using multiphoton, superresolution and structured illumination microscopy applied to living systems with the goal of aiding basic neuroscience research and development of clinical tools.
Joshua Gowin PhD
Assistant Professor
Research Focus:
Accepting Students
Developmental Neuroscience
We are interested in better understanding how brain function relates to an individual’s likelihood for engaging in risky patterns of substance use. We are currently studying adolescents in the transition period after high school to determine whether brain imaging metrics can help predict an individual’s likelihood of developing problematic patterns of use in the future. Future interests include examining the endogenous cannabinoid system to better understand how its function relates to substance use. We are also interested in acute drug administration methods to examine how neurotransmitter systems like dopamine and serotonin impact behavior and overall brain function.
Lotta Granholm-Bentley PhD, DDS
(She/Hers)
Professor
Research Focus:
Down Syndrome & Alzheimer's
Motor and Cognitive Disorders
Neuropharmacology
The research in our laboratory is focused on healthy aging and age-related neurodegenerative disorders. We are examining neuropathological alterations in postmortem materials from Parkinson's disease, Down syndrome, and Alzheimer's disease to discover novel disease mechanisms and biomarkers for early detection. We are also using animal models for these conditions.
Nathaniel Greene PhD
Associate Professor
Research Focus:
Neuroengineering
Other Systems
Sensory Systems
Dr. Greene’s research focuses on the mechanics and physiology of the auditory system and hearing. His lab focuses on the effects of using hearing restoration devices, as well as the mechanisms of hearing loss during high level sound exposure. Studies on hearing restoration devices include investigating the causes of loss of residual acoustic hearing in cochlear implant patients, and transmission of sound via bone conduction. These devices often involve substantial surgical procedures that can cause injurious levels of inner ear stimulation. Likewise, normal use of these devices stimulate the inner ear with indirect, non-ossicular pathways, which can resulting in unexpected interactions and perceptions. Current studies are focusing on quantifying these effects, investigating their sources, and developing strategies to mitigate their negative effects.
Ethan Hughes PhD
(He/Him/His)
Associate Professor
Research Focus:
Accepting Students
Cell Biology
Cell Physiology
Cellular Structure
Motor and Cognitive Disorders
Motor Disorders
Neuroimmunology
Optogenetics
Synaptic Signaling and Plasticity
The long-term goals of our work are to understand how neuron-glial interactions modulate brain function and contribute to pathology in neurodegenerative disease. Towards this goal, we study the interactions of oligodendrocyte lineage cells with neurons in the adult cerebral cortex.
Kent Hutchison PhD
Professor
Research Focus:
Accepting Students
Drugs of Abuse
My research is focused on understanding the effects of THC and CBD on the brain, immune system, and behavior across the lifespan. We are also interested in the mechanisms that mediate those effects (e.g., endocannabinoids and other lipid mediators). We utilize biomarkers (e.g., endocannabinoids and other lipid mediators) assayed with HPLC-MS and neuroimaging to examine effects in the brain.
Susan Ingram PhD
(She/Hers)
Professor
Research Focus:
Accepting Students
Cellular Physiology
Drugs of Abuse
Neuropharmacology
Optogenetics
Sensory Systems
Signal Transduction
Synaptic Signaling and Plasticity
The Ingram Lab research aims to elucidate properties of ion channels, neurotransmitter transporters, G protein-coupled receptors (GPCRs), and cellular mechanisms of synaptic plasticity associated with acute and chronic pain and drug addiction. The lab focuses predominantly on adaptations within the ventrolateral periaqueductal gray (vlPAG), a key integration site for the descending pain modulatory circuit.
Matthew Kennedy PhD
Professor
Research Focus:
Accepting Students
Down Syndrome & Alzheimer's
Neuroengineering
Neuropharmacology
Optogenetics
Signal Transduction
Synaptic Signaling and Plasticity
We study how synapses in the central nervous system are modified by experience, with the ultimate goal of understanding how these mechanisms contribute to normal cognitive function and how they break down in various brain diseases and disorders.
Sue Kinnamon PhD
Professor
Research Focus:
Sensory Systems
Research in the Kinnamon laboratory focuses on the mechanisms used by taste receptor cells to detect the sweet, salty, sour, bitter and umami tastes in the foods we eat.
Achim Klug PhD
(He/Him)
Professor
Research Focus:
Accepting Students
Cellular Physiology
Ion Channels & Biophysics
Neuroengineering
Optogenetics
Other Developmental Disorders
Other Systems
Sensory Systems
Synaptic Signaling and Plasticity
Our laboratory studies the mammalian sound localization pathway in both rodent animal models and human subjects. This circuit is involved in telling us “where” in space a sound is coming from, but it is also important to help us spatially separate multiple simultaneous and competing sounds from each other, and thus help us function in typical “cocktail party” situations. We would like to understand how this circuit operates in the healthy auditory system, and how it changes in medical conditions such as central hearing loss or autism spectrum disorder (ASD).
T. Rajendra Kumar PhD
Professor
Research Focus:
Accepting Students
Neuroendocrinology
Reproductive Biology
The Kumar Laboratory investigates all aspects of gonadotropin biology, including gonadotrope development and tumorigenesis, mechanisms of pituitary gonadotropin subunit gene expression and post-transcriptional regulation, gonadotropin biosynthesis with a focus on age-dependent glycosylation, gonadotropin secretion and action with one focus on somatic cell development and regulation in the gonads and the other on osteoclasts in the bone.
Email:raj.kumar@cuanschutz.edu
Tatiana Kutateladze PhD
Professor
Research Focus:
Accepting Students
Cancer Biology
Chromosome Biology
Gene Regulation
Macromolecular Structure
Structural Biology
My laboratory investigates molecular mechanisms of epigenetic regulation and the role of chromatin modifications in human diseases. We use high field NMR spectroscopy and X-ray crystallography to obtain atomic-resolution structures of chromatin-binding proteins and complexes involved in transcription and DNA damage repair.
Amanda Law PhD
(She/Hers)
Professor (SOM)
Research Focus:
Accepting Students
Cell Biology
Development
Developmental Neuroscience
Mouse Models
Psychiatric Disorders & Functional Imaging
Synaptic Signaling and Plasticity
My translational research program focuses on identifying the developmental and neurobiological mechanisms underlying genetic and environmental risk for schizophrenia and other neurodevelopmental disorders with the aim of improving patient outcomes. Our research combines human clinical genetics, human tissue and animal models and state of the art genomics, transcriptomics, cell biology and behavioral approaches.
Aurelie Ledreux MS, PhD
Associate Professor
Research Focus:
Down Syndrome & Alzheimer's
Motor and Cognitive Disorders
My current research interests encompass neurodegenerative diseases and healthy brain aging. My lab uses clinical samples as well as animal models to investigate neurodegeneration and neuroinflammation as underlying mechanisms in Alzheimer’s disease, Down syndrome as well as traumatic brain injury.
Kristina Legget PhD
(She/Her/Hers)
Associate Professor
Research Focus:
Psychiatric Disorders & Functional Imaging
My research utilizes neuroimaging approaches to understand neuronal circuits and mechanisms that contribute to human obesity. A goal of this work is to understand how different weight loss techniques, such as diet and exercise, affect obesity neurobiology, and how sex and gonadal hormones may influence these effects. I am also interested in the potential for exercise and diet interventions to affect the underlying neurobiology of psychiatric disorders, including schizophrenia and autism spectrum disorders.
Wendy Macklin PhD
Professor
Research Focus:
Cell Biology
Development
Developmental Biology
Developmental Neuroscience
Gene Regulation
Motor and Cognitive Disorders
Our research focuses on the following topics: (1) Signaling mechanisms that regulate oligodendrocyte differentiation and myelination; (2) The impact of ischemia on actively myelinating oligodendrocytes; (3) Demyelination induced by antibodies cloned from multiple sclerosis patients; and (4) Identification of small molecules that enhance oligodendrocyte differentiation.
Anna Malykhina PhD
Professor
Research Focus:
Ion Channels & Biophysics
Sensory Systems
The research in my laboratory has been continuously funded by the NIH/NIDDK, and we use a variety of “state-of-the-art” techniques including survival rodent surgeries, retrograde fluorescent tracers, pharmacogenetic modulation of neuronal and glial function by DREADDs, immunohistochemistry, awake cystometry, in vitro contractility studies, patch clamp recordings, cell cultures, transcriptomic and proteomic approaches, imaging and behavioral experiments. The laboratory also provides resources and support for training undergraduate and graduate students, residents and postdoctoral fellows interested in urological research.
Jessica Nelson PhD
(She/Hers)
Assistant Professor
Research Focus:
Accepting Students
Cell Biology
Development
Developmental Biology
Developmental Neuroscience
Gene Regulation
Ion Channels & Biophysics
Neuropharmacology
Sensory Systems
Synaptic Signaling and Plasticity
The Nelson Lab is focused on how sensory thresholds are established during development and how sensory processing deficits lead to human neurological disease. We use the larval zebrafish and a set of mutants identified through genetic screens aimed at identifying molecular and cellular mechanisms of sensory threshold establishment during development and sensory threshold plasticity through habituation. To better understand these mechanisms, we use a variety of techniques including behavior recording and analysis, whole brain activity mapping, and pharmacology.
Won Chan Oh PhD
Assistant Professor
Research Focus:
Accepting Students
Developmental Neuroscience
Ion Channels & Biophysics
Neuropharmacology
Optogenetics
Other Developmental Disorders
Signal Transduction
Synaptic Signaling and Plasticity
We use advanced optical imaging techniques to examine the spatiotemporal mechanisms that govern activity-dependent excitatory and inhibitory synaptic and circuit plasticity in the developing cortex.
Justin O'Hare PhD
Assistant Professor
Research Focus:
Accepting Students
Cellular Physiology
Cellular Structure
Development of software solutions
Neuroengineering
Neuropharmacology
Optogenetics
Synaptic Signaling and Plasticity
We investigate how a neuron’s dendritic arbor supports the formation of new, experience-dependent receptive fields that serve as building blocks for new memories. Using place fields in mouse hippocampal area CA1 as a model system, we combine molecular and systems neuroscience approaches to understand (1) how dendrites integrate multiple, complementary streams of synaptic input from distinct brain circuits to inform somatic action potential firing and (2) how these dendritic integrative rules are updated during place field formation and behaviorally-manifested learning.
Manisha Patel PhD
(She/Hers)
Professor
Research Focus:
Accepting Students
Epilepsy
Molecular Nutrition & Metabolic Systems
Motor and Cognitive Disorders
Neuropharmacology
The overarching theme of the laboratory is to understand the role of redox and metabolic mechanisms in epilepsy. Using biochemical, bioenergetics, transgenic and translational approaches, research in the laboratory is focused on two major areas: a) understanding the mechanisms of redox and mitochondrial dysfunction in response to epileptogenic injury and c) developing neuroprotective drugs and therapies. The lab’s research efforts have provided compelling evidence for the role of redox and mitochondrial changes following acquired epilepsy. Trainees receive rigorous and comprehensive training in neurochemistry, metabolism, mitochondrial biology, neuroprotection, whole animal and cell culture studies, analytical methods including HPLC-UV/EC, enzymology, free radical methods, drug discovery, statistical analysis, and manuscript/grant-writing/presentations. A strong commitment to mentorship, inclusivity, diversity and equity is ensured.
Anthony Peng PhD
Associate Professor
Research Focus:
Accepting Students
Ion Channels & Biophysics
Sensory Systems
We have an exquisite sense of hearing, where we are able to encode over 12 orders of magnitude in intensity and discriminate between two tones that differ in only 0.2% in frequency. These abilities originate from the auditory periphery’s ability to detect sound. A key process in the detection lies in the mechano-electrical transduction (mechanotransduction) process that happens in the stereocilia hair bundle (highlighted in middle image above). Failures of this process lead to multiple causes of genetic deafness and likely underlie some forms of noise induced and age related hearing loss. In our lab, we are interested in the molecular mechanisms of the mammalian auditory mechanotransduction process. We use state-of-the-art technology to elucidate these mechanisms.
Abigail Person
Professor;
Co-Director, Neuroscience Program
Research Focus:
Accepting Students
Motor and Cognitive Disorders
Optogenetics
Other Systems
Abigail Person's laboratory studies the contribution of the cerebellum to motor control, focusing on circuit mechanisms that support smooth, precise movement. A central idea in cerebellar physiology is that the position of the body is monitored via copies of motor commands conveyed by "corollary discharge pathways". By combining physiology, optogenetics, anatomical methods, and behavior we address how cerebellar circuitry makes movements precise. These topics are at the heart of the role of the cerebellum as a sensorimotor integrator. Disorders of this circuitry are hypothesized to contribute to some aspects of disorders such as autism and schizophrenia as well as broad motor disturbances seen in cerebellar ataxias.
Alon Poleg-Polsky MD, PhD
(He/Him)
Assistant Professor
Research Focus:
Accepting Students
Cellular Physiology
Computational Neuroscience
Gene Editing
Genomics Bioinformatics
Ion Channels & Biophysics
Neuropharmacology
Optogenetics
Sensory Systems
Synaptic Signaling and Plasticity
Visual System
We seek to describe the mechanisms that enable neural circuits to efficiently detect, amplify and transmit relevant information under diverse physiological conditions. This knowledge is required to understand how the healthy brain works and to develop strategies to treat abnormal neurological conditions. To achieve this goal, we combine advanced experimental techniques, computer modeling, and statistical analyses to study signal processing in single cells and neural networks in the retina, where neuronal and network dynamics can be studied in the well-defined context of visual processing.
Huntington Potter PhD
(He/Him)
Professor
Research Focus:
Chromosome Biology
Down Syndrome & Alzheimer's
Motor and Cognitive Disorders
Dr. Potter and other University of Colorado Alzheimer’s and Cognition researchers are developing novel diagnostics and treatments for neurodegenerative diseases including Alzheimer’s disease (AD) and Down syndrome (DS), which invariably leads to AD brain pathology by age 30-40. Research spans multiple approaches from biochemistry, cell and chromosome biology, exosomes, cerebral organoids, drug repurposing, and animal models, and then translating the discoveries into diagnostic and intervention trials in humans. One recombinant protein drug discovered by this process has benefited AD patients in its first clinical trial and is being further tested in AD and DS. Several other molecules show great promise.
Catherine Proenza PhD
Professor
Research Focus:
Cardiovascular & Pulmonary Biology
Ion Channels & Biophysics
Signal Transduction
One major focus of the lab is to understand the molecular basis for pacemaker activity within individual sinoatrial node myocytes (SAMs). To this end, we use patch clamp electrophysiology to record spontaneous action potentials and membrane currents from isolated SAMs from mice. We also use advanced patch clamp techniques like AP clamp and dynamic clamp to isolate and manipulate individual currents in SAMs.
Subbiah Pugazhenthi PhD
Professor
Research Focus:
Down Syndrome & Alzheimer's
SIRT3 Deficiency-mediated Metabolic Dysregulation in Comorbid Alzheimer's Disease.
Nidia Quillinan PhD
Associate Professor
Research Focus:
Accepting Students
Neurobiology of Stroke
Neuropharmacology
Signal Transduction
Synaptic Signaling and Plasticity
The Quillinan laboratory studies excitability and plasticity changes in the brain following cerebral ischemia. We are particularly interested in cerebellar networks that are affected by stroke and cardiac arrest. We also investigate the role of sex hormones and their receptors in acute neuronal injury and longterm hippocampal function.
Tania Reis PhD
Associate Professor
Research Focus:
Accepting Students
Cell Biology
Development
Developmental Biology
Fly Research Group
Genomics Bioinformatics
Other Developmental Disorders
Other Systems
Our lab is working on three main projects: (1) Identify pathways within the fat body that control organismal fat; (2) Determine the role in body fat regulation of a putative nutrient-responsive modifier of physical activity; and (3) Develop a functional map of neuronal control of body fat.
Katherine Rennie PhD
Associate Professor
Research Focus:
Accepting Students
Other Systems
Sensory Systems
Synaptic Signaling and Plasticity
This laboratory's research is focused on hair cells of the vestibular system. The vestibular system of the inner ear senses accelerations of the head and interacts with other systems to produce the sensation of balance. It is estimated that more than one third of adults in the US experience vestibular dysfunction at some time in their life. However the mechanisms underlying normal and abnormal processing of vestibular sensory signals are not well understood. Our research aims to elucidate how signals are processed in the peripheral vestibular system using rodent models.
Diego Restrepo PhD
Professor
Research Focus:
Cell Biology
Cellular Physiology
Development
Neuroengineering
Optogenetics
Other Systems
Sensory Systems
I am a systems neuroscientist with a background in physics studying sensory decision making and neurological disorders using novel genomics, transcriptomics, computational neuroscience, automated behavioral testing, advanced neurophotonics and multielectrode arrays. I believe that diversity, equity and inclusion are key in neuroscience inquiry.
Darleen Sandoval PhD
Professor
Research Focus:
Accepting Students
Molecular Nutrition & Metabolic Systems
Neuroendocrinology
Other Systems
The Sandoval Lab conducts a variety of research studies focused on the role of the gut-brain-axis on regulating body weight and metabolism with the aim to gain a better understanding the role of the gut-brain axis in physiology and in the pathophysiology of obesity and Type 2 diabetes mellitus. We use a combination of techniques including genetic mouse models, bariatric surgery, and in depth metabolic phenotype including in vivo assessment of glucose and lipid metabolism.
Stephen Santoro PhD
Assistant Professor
Research Focus:
Accepting Students
Cell Biology
Cellular Physiology
Development
Developmental Biology
Developmental Neuroscience
Sensory Systems
Stem Cells
We are interested in how life experience guides the development and adaptation of the mammalian nervous system. We recently discovered that, in mice, olfactory experience regulates the relative birthrates of the > 1000 distinct olfactory sensory neuron subtypes in an odor-specific manner. These findings have led us to hypothesize that life-long olfactory sensory neurogenesis performs an unknown adaptive role, in addition to the known reparative one. We are currently investigating the mechanism and function of this phenomenon. These studies are anticipated to elucidate fundamental aspects about how the olfactory system develops, adapts, and frequently loses function with age and disease.
Debosmita Sardar PhD
Assistant Professor
Research Focus:
Accepting Students
Epigenetics
Neuropharmacology
Signal Transduction
At the Glial Epigenetics Lab, we are interested in the big broad question of how we perceive and respond to the world around us through our senses. Towards this, we are specifically interested in the sensory experience of smell. In our lab, we use mouse models to approach the smell system at a cellular scale of studying non-neuronal glial cells, and at a molecular scale of epigenetics. Together, our work will provide insights into how glial cells and epigenetics play together to shape sense of smell.
Joseph Schacht PhD
Associate Professor
Research Focus:
Psychiatric Disorders & Functional Imaging
I am a clinical neuroscientist focused on using neurobiological measures to improve treatment for alcohol and addictive disorders. My training and expertise span behavioral genetics, functional neuroimaging, experimental pharmacology, and “human laboratory” paradigms.
Benjamin Scholl PhD
(He/Him)
Assistant Professor
Completed Mentor Training Course
Research Focus:
Accepting Students
Developmental Neuroscience
Optogenetics
Other Systems
Sensory Systems
Synaptic Signaling and Plasticity
We are interested in mechanisms of cortical sensory processing: How do neurons transform information from the world and into electrical activity used to mediate perception and behavior. We use multiphoton synaptic imaging, read/write optogenetics, and chronic neuropixels recordings to study visual processing and the development of complex behaviors.
Nathan Schoppa PhD
Professor
Co-Director, Neuroscience Program
Research Focus:
Ion Channels & Biophysics
Optogenetics
Sensory Systems
Synaptic Signaling and Plasticity
Our lab is interested in understanding mechanisms and function of brain circuits involved in processing olfactory information. Our focus is on two structures, the olfactory bulb and the piriform cortex, asking basic questions about what neurons are present, how they are connected, and how groups of neurons work to effect a particular circuit output.
Tamim Shaikh PhD
Professor
Director, Human Medical Genetics and Genomics Program
Research Focus:
Down Syndrome & Alzheimer's
Motor and Cognitive Disorders
Other Developmental Disorders
My research focuses on three major areas; i) Copy Number Variation in Human Disease, ii) Genome Instability and Mechanisms of Rearrangement and iii) Discovery and Functional Characterization of Candidate Disease Genes.
Julie Siegenthaler PhD
Associate Professor
Research Focus:
Accepting Students
Development
Developmental Neuroscience
Our lab studies the interplay between the CNS and its vital support structures the meninges and the brain vasculature. We have meninges and brain vascular projects in CNS development, the adult brain and CNS injury and disease.
Katharine Smith PhD
Associate Professor
Research Focus:
Accepting Students
Ion Channels & Biophysics
Motor and Cognitive Disorders
Neurobiology of Stroke
Neuropharmacology
Psychiatric Disorders & Functional Imaging
Signal Transduction
Synaptic Signaling and Plasticity
Research in our lab is focused on understanding how the excitability of neurons is regulated by excitatory and inhibitory synaptic plasticity. Many neuropsychiatric diseases and brain pathologies exhibit alterations in neuronal excitability in key brain regions associated with learning and memory. Our goal is to understand the molecular mechanisms of how excitatory and inhibitory synapses function together to maintain appropriate excitability of the neuron, and how this is disrupted in diseases such as autism and schizophrenia. To reach this goal we image both excitatory and inhibitory synapses using cutting-edge microscopy, including super-resolution imaging, supported by electrophysiology and biochemical analysis.
Joel Stoddard MD
Associate Professor
Research Focus:
Developmental Neuroscience
Dr. Stoddard is interested in understanding and developing experimental, learning-based therapies for emotional problems, such as severe irritability, that affect children and adolescents. He applies clinical phenotyping, psychometrics, functional magnetic resonance imaging, and computational modeling in his work
John Thompson PhD
(He/Him)
Associate Professor
Research Focus:
Motor and Cognitive Disorders
Neuroengineering
Other Systems
Psychiatric Disorders & Functional Imaging
Our computational neuroscience research program uses advanced signal processing and quantitative modeling to achieve three main goals: (1) analyze and interpret large-scale neural data, (2) develop and validate computational models of brain function, and (3) translate these findings to broader scientific and clinical contexts. By integrating experiments, theoretical perspectives, and computational techniques, we aim to deepen our understanding of how neural circuits drive cognition and behavior. Ultimately, our work strives to transform these insights into innovative technologies and meaningful improvements in human health.
Scott Thompson PhD
Professor
Research Focus:
Neuropharmacology
Psychiatric Disorders & Functional Imaging
Synaptic Signaling and Plasticity
Our mission is to discover the changes that occur in the brain in patients with major depression so that we can identify better therapies to treat depression.
Slobodan Todorovic MD, PhD
Professor
Research Focus:
Accepting Students
Ion Channels & Biophysics
Neuropharmacology
Sensory Systems
Signal Transduction
The role of T-type (low-voltage-activated, LVA) calcium channels in the molecular mechanisms of anesthesia and analgesia.
Daniel Tollin PhD
Professor
Research Focus:
Accepting Students
Developmental Neuroscience
Neuroengineering
Other Developmental Disorders
Other Systems
Sensory Systems
The role of auditory environmental experience, both normal and abnormal, on the development and maintenance of auditory function.
Jason Tregellas PhD
Professor
Research Focus:
Psychiatric Disorders & Functional Imaging
Dr. Tregellas’ research career has focused on understanding the neurobiology of disorders such as schizophrenia, and on processes related to food intake behaviors and obesity.
Ming-Feng Tsai PhD
Assistant Professor
Research Focus:
Accepting Students
Ion Channels & Biophysics
Signal Transduction
My research focuses on molecular mechanisms and physiological functions of transporters and ion-channels, particularly those in mitochondria. We approach questions using a wide range of tools, including membrane-biochemistry, electrophysiology, cryo-electron microscopy, animal models, and imaging.
Kenneth Tyler MD
Professor
Research Focus:
Neurovirology
His laboratory uses a variety of neurotropic viruses, including reoviruses, Enterovirus D-68, and Flaviviruses (West Nile, Japanese encephalitis and Zika) to study the pathogenesis of viral CNS infections. A particular interest has been in understanding the nature of specific cellular pathways (signaling, gene expression, apoptosis) that are activated during neurotropic viral infections and that lead to neuronal injury and death. The laboratory uses primary cell cultures, ex vivo slice cultures of brain and spinal cord, and murine models to study virus-cell interactions.
Email:ken.tyler@cuanschutz.edu
Kristin Uhler PhD
Associate Professor
Research Focus:
Sensory Systems
I am interested in language development in children with and without hearing loss. My focus is developing approaches to determine how infants discriminate speech sounds and discrimination in early infancy and how this relates to later language development.
Sukumar Vijayaraghavan PhD
Professor
Research Focus:
Ion Channels & Biophysics
Neuropharmacology
Optogenetics
Sensory Systems
Synaptic Signaling and Plasticity
We are a lab that works on cholinergic signaling in the mammalian brain. Cholinergic systems, via the actions of released acetylocholine, are thought to play an essential role in behaviors involving attention, learning and memory. Impairment of cholinergic signaling is implicated in many neurodegenerative diseases likes Alzheimer's and Parkinson's; and in psychiatric disorders like schizophrenia. However, we know very little about mechanisms underlying signaling by this important neurotransmitter. Our lab strives to remedy this deficit in our knowledge.
Email:sukumar.v@cuanschutz.edu
Cristin Welle PhD
Associate Professor
Research Focus:
Accepting Students
Motor and Cognitive Disorders
Neuroengineering
Other Developmental Disorders
Sensory Systems
Dr. Welle’s BIOElectrics Lab investigates how neurological medical devices interact with the nervous system. We dissect circuit-level structural and functional implications of neuromodulatory and brain-computer-interface devices using optogenetics, chronic electrophysiology and longitudinal in-vivo imaging in animal models. Our goal is to understand the dynamic interactions between devices and neural circuits in the context of translational neurotechnology.
Clyde Wright MD
(He/Him)
Professor
Research Focus:
Accepting Students
Innate Immunity
Dr. Clyde Wright, MD, leads a research lab in the field of Neonatology, with a primary focus on understanding how inflammatory insults encountered during the perinatal period contribute to the various morbidities observed in prematurely born infants. Dr. Wright's lab aims to investigate cell-specific innate immune pathways to identify potential therapeutic targets for improving the outcomes of these vulnerable patients.
Alison Xie PhD
(She/Hers)
Assistant Professor
Research Focus:
Cardiovascular/Pulmonary/Renal/GI Physiology
Cell Biology
Neuropharmacology
Other Systems
The Xie lab studies satellite glia-neuron interactions in the peripheral nervous system. The Xie lab studies the neuromodulatory role of satellite glia in regulating heart rate, blood pressure, and bladder contractility using pharmacogenetic and optogenetic manipulation of glial cell signaling pathways combined with physiological recordings of cardiovascular and bladder function. The current research projects include:1) The analgesic role of sensory satellite glial cells in bladder overactivity and chronic pelvic pain; 2) The neuroactive role of autonomic satellite glial cells in enhancing hollow-organ contractions (heart, bladder).; and 3), the sex differences in glial-regulation of organ functions (resting blood pressure, bladder sensitivity).