FACULTY & RESEARCH

The research interests of program faculty span the breadth of molecular biology.

Faculty interests include:

  • DNA replication, RNA transcription, localization and mRNA translation
  • Bioinformatics and computational biology
  • Intracellular regulation of cell division, signaling, cell migration and cell polarization Regulation of cell stress response and molecular assemblies
  • Genetic and molecular mechanisms governing organismal development, tissue differentiation and cell fates
  • Structural biology of macromolecular machines, proteins and nucleic acids
  • Pathogenic mechanisms of infectious and non-communicable disease
  • Drug discovery and molecular mechanisms of drug resistance and response
  • Technology and methods development, including optogenetics and gene editing

Note: "MOLB Non-Training Faculty" do not serve as thesis mentors for Molecular Biology students.

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Scott Alper PhD

Associate Professor
Research Focus: Cancer Biology Gene Regulation Inflammation
Dr. Alper's laboratory is focused on understanding the regulation of the innate immune response, particularly as it relates to the basis for inflammatory disease.

Steve Anderson PhD

Professor MOLB Non-Training Faculty
Research Focus: Cancer Biology
Our major focus over the last five years has been to understand the role of the hexose transporter Glut1 in mammary tumorigenesis.

Bruce Appel PhD

Professor
Research Focus: Accepting Students Development Developmental Biology Developmental Neuroscience
We investigate the genetic, molecular and cellular basis of brain development and myelination using zebrafish as a model system.

Francisco Asturias PhD

Professor
Research Focus: Gene Regulation Macromolecular Structure Microbiology Virology
Despite including many different proteins, macromolecular complexes often display minimal enzymatic activity. This suggests that conformational changes and interactions are fundamental to their molecular mechanism. My group uses cryo-electron microscopy to characterize the structure, conformational states and interactions of macromolecular complexes involved in essential cellular processes. We correlate that structural information with biochemical and functional data to establish the mechanism of these remarkable cellular machines.

David Barton PhD

Professor
Research Focus: Macromolecular Structure Microbiology Virology
The Barton lab studies RNA viruses - viral RNA replication - and host-pathogen interactions involving viral RNA and endoribonucleases.

Emily Bates PhD

Associate Professor
Research Focus: Accepting Students Cellular Physiology Development Developmental Biology Developmental Neuroscience Gene Regulation Genomics Bioinformatics Neuropharmacology Other Developmental Disorders
Understanding how ion channels contribute to morphological development and microtubules are regulated for brain development.

David Bentley PhD

Professor
Research Focus: Gene Regulation RNA Bioscience
Our research asks how the RNA polymerase II transcriptional machinery and RNA processing factors work together to achieve coordinated synthesis and maturation of messenger RNA (mRNA).

Joshua Black PhD

Assistant Professor
Research Focus: Accepting Students Cancer Biology Genomics Bioinformatics
My lab studies how cells use epigenetics to control gene amplifications. We have identified epigenetic pathways that cells use to create transient increases in gene copy number. These copy number changes play roles in tumor development, progression and drug resistance. By understanding the fundamental mechanisms that govern copy number control we hope to allow better cancer therapies.

Matthew Burchill PhD

Assistant Professor
Research Focus: Accepting Students
Research in our laboratory leverages our expertise in immunology, molecular biology and model systems of liver disease to explore the early and late events that influence the progression of chronic liver disease.

M. Cecilia Caino PhD

(she/her/hers)
Assistant Professor
Research Focus: Accepting Students Cancer Biology Cellular Structure Signal Transduction
Our group aims to understand how mitochondria reprogramming in tumors impact cellular behaviors that drive progressive and lethal cancer. We use a broad repertoire of biochemistry, cell biology, live cell imaging and animal models to study the impact of mitochondria shape, number and subcellular distribution in metastatic dissemination.

Mair Churchill PhD

Professor MOLB Non-Training Faculty
Research Focus: Accepting Students Chromosome Biology Gene Regulation Genomics Bioinformatics Macromolecular Structure Microbiology Virology
My lab is interested in understanding the molecular basis of essential processes that regulate gene expression. We use biophysical, biochemical methods, and structural methods, including X-ray crystallography. Our insights into these fundamental mechanisms will contribute to a better understanding and ability to regulate gene expression processes involved in human diseases and will assist in drug development efforts. Our studies focus on the following questions: (1) How is chromatin structure modulated for DNA-dependent processes? and (2) How do transcription factors and pioneering factors activate gene expression?

Diana Cittelly PhD

(she/her/hers)
Associate Professor
Research Focus: Cancer Biology Inflammation Neuropharmacology Signal Transduction
Deciphering the mechanisms underlying increased risk of brain metastases in young women with triple negative breast cancer. These include ovarian estrogen effects on reactive astrocytes that results in paracrine activation of EGFR and TRKB signaling in brain metastatic cells.

Sean Colgan PhD

Professor
Research Focus: Cardiovascular/Pulmonary/Renal/GI Physiology Cellular Structure
The Colgan Lab studies mucosal inflammation with focus on intestinal inflammation in the context of inflammatory bowel disease and other GI diseases. Studies are aimed at understanding how epithelial and endothelial cells coordinate barrier function and inflammatory responses at mucosal surfaces. Our lab takes a multifaceted approach by investigating the relationships between gut microbiota, host immune system, genetic background, and environmental influences as it pertains to mucosal health and disease, with research emphasis on energy metabolism, host-microbe interactions, hypoxia-inducible factor, and innate immunity.

Julia Cooper PhD

Professor Chair, Biochemistry & Molecular Genetics
Research Focus: Chromosome Biology
While chromosome linearity is so universal among eukaryotes that we assume it to be evolutionarily advantageous, formidable challenges are presented by linear chromosome ends, as they resemble damage-induced DNA breaks, which are vulnerable to degradation and end-joining pathways that provoke genome instability. Telomeres protect chromosome ends from these hazards, and compromised telomere maintenance is a confirmed driver of both tumorigenesis and degenerative diseases. Our group has uncovered key principles underlying these ‘classical’ protective telomere functions. Moreover, we are discovering that the special properties of telomeres provide cells not only with ‘protective caps’ for chromosomes, but also with remarkable regulatory opportunities. For instance, meiotic telomeres control the assembly/disassembly and functions of two additional key structures, centromeres and the nuclear envelope. These discoveries provide novel rationales for the evolutionary dominance and persistence of chromosome linearity.

Shaodong Dai PhD

Associate Professor
Research Focus: Accepting Students Cellular Structure Diabetes Infectious Disease Rheumatoid Arthritis
Research interests include: (1) CAR T and engineered T cell therapies of autoimmune diseases; (2) Mechanisms of T cell mediated metal hypersensitivities; (3) Mechanisms of T cell recognition of autoantigens in Type 1 diabetes and RA; and (4) Redox signaling and drug design in the immune diseases and infectious diseases.

James Degregori PhD

(he/him/his)
Professor
Research Focus: Cancer Biology Cell Biology
Exploring the conditions that foster somatic evolution and discovering cancer vulnerabilities.

Patricia Ernst PhD

(she/her/hers)
Professor
Research Focus: Accepting Students Cancer Biology Gene Regulation
Our group focuses on epigenetic mechanisms regulating normal hematopoiesis and leukemia focusing on MLL-family histone methyltransferases.

Tom Evans PhD

Associate Professor
Research Focus: Developmental Biology Gene Regulation Genomics Bioinformatics
Cytoplasmic mRNA regulation is very important during oogenesis, early embryogenesis, and during stem cell divisions that occur throughout development. The mechanisms that regulate cytoplasmic mRNAs and that tie this control to the development of living cells are poorly understood. Recent studies hint that the mechanisms are similar in many animals and that they are important for various human diseases. We are exploring this problem in the small nematode worm, Caenorhabditis elegans.

Katherine Fantauzzo PhD

Associate Professor
Research Focus: Accepting Students Developmental Biology
A fundamental question in developmental biology is how cells communicate with one another and the environment. Receptor tyrosine kinases (RTKs) contribute to this communication by binding to growth factors at the cell surface and activating various intracellular signaling pathways to elicit responses with broad roles in developmental cellular processes. A subset of RTK families has been shown to regulate the activity of neural crest cells (NCCs) and the development of their derivatives in mammalian systems. NCCs are migratory, multipotent cells that play a critical role in vertebrate development. Cranial NCCs originate from the forebrain to the hindbrain and populate the frontonasal prominence and pharyngeal arches 1-4. These cells give rise to the bone and cartilage of the frontonasal skeleton, among other derivatives. Our lab is focused on investigating the mechanism and function of signaling through a particular RTK family, the platelet-derived growth factor (PDGF) receptor family, in development of the cranial NCC-derived craniofacial skeleton.

Heide Ford PhD

(she/her/hers)
Professor
Research Focus: Accepting Students Cancer Biology Gene Regulation Genomics Bioinformatics Signal Transduction
Our laboratory focuses on a specific family of homeoproteins, the Six family, and their transcriptional cofactors, Eya and Dach. The Six1 homeobox gene is overexpressed in 50% of primary breast cancers and 90% of metastatic lesions, and its overexpression.

Craig Forester MD, PhD

Assistant Professor
Research Focus: Cancer Biology Gene Regulation
Our lab seeks to define out epitranscriptomic changes impact specificity in protein synthesis across an array of contexts including pediatric bone marrow failure and oncogenesis predisposition.

Santos Franco PhD

Associate Professor
Research Focus: Accepting Students Development Developmental Neuroscience
The cerebral cortex is the control center of most of our higher-level brain functions, including thought, language, memory and emotion. During cortical development, billions of neurons and glia must be precisely specified and assembled into the intricate circuits that underlie these complex tasks. Disruption of these processes is associated with many devastating human neurological disorders, including epilepsy, schizophrenia, autism and intellectual disability. Our lab studies several processes involved in the formation and function of neural circuits in the cerebral cortex.

James Hagman PhD

Professor MOLB Non-Training Faculty
Research Focus: Gene Regulation
My laboratory’s goals include understanding how the nuclear proteins Early B cell Factor (EBF) and Pax5 (B cell-specific activator protein) regulate B lineage specification, commitment and the immune response to antigens.

Lydia Heasley PhD

Assistant Professor
Research Focus: Accepting Students Chromosome Biology Microbiology Virology
How does the structure of a genome evolve over time? Our research investigates the molecular causes and phenotypic consequences of the broadly defined family of genomic features known as structural variations (SVs). SVs like aneuploidy, loss-of-heterozygosity, and copy number alteration are pervasive, yet poorly understood genomic elements which contribute significantly to the genotypic and phenotypic diversity of eukaryotic populations. Our current work is addressing many fascinating and important biological questions focused on understanding how SVs arise in the genome, and how these variations contribute to genome stability and evolution, phenotypic diversity, and cellular and organismal fitness.

Jay Hesselberth PhD

Associate Professor
Research Focus: Chromosome Biology Gene Regulation Genomics Bioinformatics RNA Bioscience
We are a research laboratory of RNA biologists, technology developers, and data analysts focused on discovering and translating fundamental principles of RNA regulation. A major effort in the lab is to understand how RNA damage and repair are integrated with stress responses by combining method development, bioinformatics, genetics, biochemistry, and cell biology.

V. Michael Holers MD

Professor
Research Focus: Cellular Structure
Dr. Holers research group performs both basic and translational research. A longstanding interest has been to decipher the roles of complement receptors and membrane regulatory proteins in the immune response, with a special emphasis on autoimmune diseases.

Cheng-Jun Hu PhD

Associate Professor MOLB Non-Training Faculty
To distinguish the role of HIF-1a and HIF-2a in cancer progression, Molecular Mechanisms of Hypoxic Transcriptional Response.

Mingxia Huang PhD

Associate Professor MOLB Non-Training Faculty
Research Focus: Cancer Biology Chromosome Biology
Function and regulation of the DNA damage response.

Ethan Hughes PhD

Associate Professor
Research Focus: Accepting Students Cell Biology Cellular Structure Motor and Cognitive Disorders Optogenetics Synaptic Signaling and Plasticity
The long-term goals of our work is to understand how neuron-glial interactions modulate brain function and contribute to pathology in neurodegenerative disease. Towards this goal, we study the interactions of oligodendrocyte lineage cells with neurons in the adult cerebral cortex.

Sujatha Jagannathan PhD

Assistant Professor
Research Focus: Accepting Students Cell Biology Gene Regulation Genomics Bioinformatics RNA Bioscience
Our lab studies how cells detect and degrade aberrant RNAs, and how dysregulation of this surveillance process contributes to human muscle development and disease.

Aaron Johnson PhD

Associate Professor Director, Biomedical ScIences Program
Research Focus: Accepting Students Chromosome Biology Gene Regulation Genomics Bioinformatics
Our work focuses on the formation and regulation of chromatin domains and their ultimate roles in epigenetic genome regulation. We are particularly interested in the mechanisms of heterochromatin establishment and function.

Craig Jordan PhD

(he/him/his)
Professor
Research Focus: Accepting Students Cancer Biology Developmental Biology
Dr. Jordan serves as the Chief of the Hematology Division and directs a research program focused on the development of novel therapies for the treatment of leukemia.

Igor Kogut PhD

Assistant Professor
Research Focus: Accepting Students Cell Biology Cellular Structure Stem Cells
Investigating the mechanisms leading to cellular reprogramming and aging, as well as induced Pluripotent Stem Cell (iPSC)-associated cellular rejuvenation.

Elizabeth Kovacs PhD

Professor
Research Focus: Cellular Structure Drugs of Abuse Inflammation
The effects of advanced age and alcohol misuse on inflammatory responses after burn trauma or infection.

Tatiana Kutateladze PhD

Professor
Research Focus: Accepting Students Cancer Biology Chromosome Biology Gene Regulation Ion Channels & Biophysics Macromolecular Structure Neuropharmacology Structural Biology
Research in my group focuses on the molecular mechanisms of epigenetic regulation and phosphoinositide signaling. We apply high field NMR spectroscopy, X-ray crystallography and a wide array of biochemical and molecular biology approaches to characterize the atomic-resolution structures and functions of chromatin- and lipid-binding proteins implicated in cancer and other human diseases.

Wendy Macklin PhD

Professor
Research Focus: Cell Biology Development Developmental Biology Developmental Neuroscience Gene Regulation Motor and Cognitive Disorders
Our research focuses on the following topics: (1) Signaling mechanisms that regulate oligodendrocyte differentiation and myelination; (2) The impact of ischemia on actively myelinating oligodendrocytes; (3) Demyelination induced by antibodies cloned from multiple sclerosis patients; and (4) Identification of small molecules that enhance oligodendrocyte differentiation.

Allison McClure PhD

(She/Her)
Assistant Professor
Research Focus: Accepting Students Cell Biology
Cell cycle regulation of DNA replication

Michael McMurray PhD

Associate Professor
Research Focus: Cell Biology Cellular Structure Macromolecular Structure
Our research focuses on identifying molecular mechanisms underlying the assembly of macromolecular complexes, with a focus on multisubunit complexes formed by septin proteins. All cellular processes require the function of multisubunit complexes, and while much attention has been given to solving the final structures of such assemblies, comparatively little is known about how individual subunits adopt oligomerization-competent conformations and find their partner subunits in the crowded, dynamic cellular milieu.

Jeffrey Moore PhD

(he/him/his)
Associate Professor Director, Cell Biology, Stem Cells & Development Program
Research Focus: Accepting Students Cell Biology Chromosome Biology Genomics Bioinformatics
Molecular regulation of the microtubule network in cell division and disease.

Christian Mosimann PhD

Associate Professor
Research Focus: Accepting Students Cell Biology Development Developmental Biology Gene Regulation
The aim of our lab's research is to understand how cells acquire their fates during development and how these processes go wrong in congenital disease. As principal model, we use the zebrafish (Danio rerio) to investigate the cell fate control of mesodermal lineages, in particular of the lateral plate mesoderm (LPM).

Neelanjan Mukherjee PhD

Assistant Professor Admissions Committee Chair, Molecular Biology Program
Research Focus: Cancer Biology Gene Regulation Genomics Bioinformatics RNA Bioscience
Systems Biology of Human RNA Regulatory Networks.

Catherine Musselman PhD

Associate Professor Director, Structural Biology and Biochemistry Program
Research Focus: Chromosome Biology
Our research program addresses how chromatin regulatory proteins associate with histones in response to chromatin signaling events. We are specifically interested in how histone reader domains associate with modified histones in the chromatin relevant context of the nucleosome. We are using NMR spectroscopy along with other biophysical and structural techniques to build models of these complexes and understand how they are regulated. ​Results of these studies will provide insight into fundamental processes of genome regulation, the etiology of human disease, and lay the groundwork for the development of targeted therapeutics.

Jessica Nelson PhD

Assistant Professor
Research Focus: Accepting Students Cell Biology Development Developmental Biology Developmental Neuroscience Gene Regulation
Our recent work has identified multiple loci within the nervous system that may be relevant for driving habituation learning. We are investigating whether and how activity within these neuronal populations changes during learning and how activity is disrupted in animals that cannot learn.

James Nichols PhD

Assistant Professor
Research Focus: Accepting Students Development Developmental Biology
We are interested in the mechanisms that keep development on track, even when cells are faced with deleterious changes like genetic mutations.

Chad Pearson PhD

(he/him/his)
Associate Professor
Research Focus: Accepting Students Cell Biology Cellular Structure Macromolecular Structure
Centrosome and cilia biology in cell division, motility, and disease.

Eric Pietras PhD

Associate Professor
Research Focus: Accepting Students Cancer Biology Cell Biology Development Developmental Biology Inflammation Molecular Nutrition & Metabolic Systems Stem Cells
Interplay between inflammation and metabolism as a driver of leukemia development; targeting of pre-malignant and malignant blood-forming stem cells.

Huntington Potter PhD

Professor
Research Focus: Chromosome Biology Down Syndrome & Alzheimer's Motor and Cognitive Disorders
Neurodegenerative diseases and Down Syndrome.

Rytis Prekeris PhD

Professor Director, Molecular Biology Program
Research Focus: Accepting Students Cancer Biology Cell Biology Cellular Structure Development Developmental Biology
Regulation of cell division, cell polarity and cell migration.

Srinivas Ramachandran PhD

Assistant Professor
Research Focus: Cancer Biology Chromosome Biology Gene Regulation Genomics Bioinformatics
The long-term goal of the Ramachandran Lab is to understand how distinctive chromatin landscapes that reflect cellular identity are established and maintained.

Tania Reis PhD

Associate Professor
Research Focus: Accepting Students Cell Biology Development Developmental Biology Fly Research Group Genomics Bioinformatics Other Developmental Disorders Other Systems
Our lab is working on three main projects: (1) Identify pathways within the fat body that control organismal fat; (2) Determine the role in body fat regulation of a putative nutrient-responsive modifier of physical activity; and (3) Develop a functional map of neuronal control of body fat.

Jennifer Richer PhD

(she/her/hers)
Professor Dean, Graduate School
Research Focus: Accepting Students Cancer Biology
The focus of my research is on the role of estrogen and progesterone receptors in breast and gynecological cancers, mechanisms of resistance to hormone therapy, and the differences between hormone dependent and independent breast cancer.

Olivia Rissland PhD

(she/her/hers)
Associate Professor
Research Focus: Accepting Students Cell Biology Developmental Biology Gene Regulation Genomics Bioinformatics Microbiology Virology RNA Bioscience
Our goal is to understand how translation impacts mRNA stability, and to place gene regulation in the contexts of broader biological processes.

Brian Russo PhD

Assistant Professor
Research Focus: Cell Biology Microbiology Virology
The Russo lab is interested in understanding how bacterial pathogens interact with their hosts. As a model, we investigate the pathogenesis of Shigella flexneri, which infects cells of the colon and causes diarrhea in humans.

Charles Sagerstrom PhD

Professor
Research Focus: Accepting Students Cell Biology Development Developmental Biology Gene Regulation Genomics Bioinformatics
Our lab uses zebrafish to study transcriptional and epigenetic control of key transitions during embryogenesis. We are particularly interested in understanding the onset of zygotic transcription at the maternal-to-zygotic transition, ​and in unraveling the transcription orogram driving neural cell fates beginning during gastrulation.

Stephen Santoro PhD

Assistant Professor
Research Focus: Accepting Students Cell Biology Cellular Physiology Development Developmental Biology Developmental Neuroscience Sensory Systems Stem Cells
We are interested in how life experience guides the development and adaptation of the mammalian nervous system. We recently discovered that, in mice, olfactory experience regulates the relative birthrates of the > 1000 distinct olfactory sensory neuron subtypes in an odor-specific manner. These findings have led us to hypothesize that life-long olfactory sensory neurogenesis performs an unknown adaptive role, in addition to the known reparative one. We are currently investigating the mechanism and function of this phenomenon. These studies are anticipated to elucidate fundamental aspects about how the olfactory system develops, adapts, and frequently loses function with age and disease.

Matthew Sikora PhD

(he/him/his)
Associate Professor
Research Focus: Accepting Students Cancer Biology
The overall goal of the Sikora Laboratory is to understand mechanisms of response and resistance to steroid hormones and anti-estrogen therapies in breast cancer, with a special emphasis on invasive lobular carcinoma of the breast.

Lori Sussel PhD

Professor
Research Focus: Accepting Students Cellular Structure Development Developmental Biology Genomics Bioinformatics
The main focus of the Sussel lab is to understand the complex transcriptional networks that regulate development, differentiation and function of the pancreas.

Matthew Taliaferro PhD

Assistant Professor
Research Focus: Accepting Students Cell Biology Cellular Structure Gene Regulation Genomics Bioinformatics RNA Bioscience
We study how the expression of genetic information is spatially regulated within a cell.

Beth Tamburini PhD

Associate Professor Co-Director, Immunology Program
Research Focus: Cancer Biology Cellular Structure Gene Regulation
The Tamburini lab focuses on understanding how immune cells interact and traffic through the lymphatic vasculature to facilitate an appropriate immune response. We are also interested in the trafficking of small molecules and antigens through the lymphatic vasculature and into draining lymph nodes during infection, vaccination or during chronic disease such as non-alcoholic steatohepatitis, alcohol related liver disease and primary schlerosing cholangitis.

Chandra Tucker PhD

Professor
Research Focus: Accepting Students Cellular Structure Gene Regulation Genomics Bioinformatics Signal Transduction
Research in the Tucker Lab focuses on developing new tools to sense and manipulate the intracellular environment, and using these tools to understand dynamic cellular processes. A major focus is in developing ways that we can inducibly regulate and control fundamental molecular events such as protein trafficking, proteolysis, gene expression, and intracellular signaling using inducers such as light (optogenetic tools) or chemicals.

Linda van Dyk PhD

Professor
Research Focus: Cancer Biology Gene Regulation Microbiology Virology
The van Dyk lab studies the interactions between virus and host in health and disease. Specifically, our work focuses on gammaherpesviruses.

Andres Vazquez-Torres DVM, PhD

Professor
Research Focus: Cellular Structure Genomics Bioinformatics Microbiology Virology
The research in the Vázquez-Torres lab uses state-of-the-art biochemical, genetic and molecular biology approaches to understand the molecular mechanisms by which reactive species mediate resistance of macrophages against intracellular bacteria, as well as the adaptive strategies that boost antioxidant and antinitrosative defenses of pathogenic bacteria.

Eszter Vladar PhD

Assistant Professor
Research Focus: Accepting Students Cell Biology Cellular Structure Gene Regulation
We use mice and primary mouse and human cell culture to study how multiciliated cells adopt their cell fate, build cilia and orient the cilia for directional clearance. We investigate the pathways that drive these processes during normal development and regeneration and study how they are misregulated in human disease. Our research has the potential to develop novel biomarkers and therapeutics for individuals suffering from chronic airway diseases.

Beat Vogeli PhD

Associate Professor
Research Focus: Macromolecular Structure
We develop NMR methods and apply them together with other biophysical methods to study biologically relevant systems at atomic resolution: Diverse dynein motor adaptors and their cargos, allostery in key cell regulator Pin1, Olduvai domains involved in brain function and disease, and various RNA and DNA segments.

Martin Voskuil PhD

Associate Professor
Research Focus: Cellular Structure Microbiology Virology
Mycobacterium tuberculosis survival during latent disease.

Trevor Williams PhD

Professor
Research Focus: Cancer Biology Development Developmental Biology Gene Regulation
Transcriptional regulation of mouse embryonic development.

Ning Zhao PhD

Assistant Professor
Research Focus: Accepting Students Cancer Biology Cell Biology Gene Regulation Macromolecular Structure RNA Bioscience
My lab focuses on developing technologies that enable tracking the full life cycle of proteins in real time with high spatiotemporal resolution in their native intracellular environments. This will help us understand when, where, and how proteins are synthesized, folded, modified, and degraded in both healthy and diseased cells.

Rui Zhao PhD

Professor
Research Focus: Accepting Students Cancer Biology Gene Regulation Macromolecular Structure RNA Bioscience
My lab studies the role of the Six1/Eya transcriptional complex and splicing in cancer. We are also developing small molecule or RNA-based approaches to target the Six1/Eya complex or splicing as potential cancer therapeutics.