Scope:

The Omics WG ensures the availability of high-quality omics datasets harmonized across Affiliate Cohorts to Consortium-wide and prioritized Consortium projects in DEFINE-T2D. Initial focus for this WG is to inventory existing data and formulate a quality control (QC) and harmonization plan for genetic and metabolomic data.

Priorities:

• Maintain list of ‘omics data availability
• Provide guidance on QC and harmonization of ‘omics data
• Summarize imputation panels/methods across cohorts and provide guidance on imputation methods
• Address ancestry considerations in genetic and other omics analyses
• Provide guidance on the use of polygenic risk scores (PRS)

Co-conveners:

• Nichole Allred
• Eric Gamazon

Members :

• Laura Brenner
• Zsu-Zsu Chen
• Joanne Cole
• Varinderpal (Vicky) Kaur
• Swapan K. Das
• Joohyun Kim
• Iain Konigsberg
• Kevin Lu
• Josep Mercader
• Maggie Ng
• Qibin Qi
• Mary Rooney
• Jerome Rotter
• Magdalena (Magda) Sevilla
• Tamar Sofer
• Lukasz Szczerbinski
• Kent Taylor
• Miriam Udler
• Ivana Yang

NIH Project Scientist:

• Norann Zaghloul

BRC Project Manager:

• Aastha Kakar

Scope:

The Phenotypes WG is responsible for defining data format and documentation requirements for Study Site and Affiliate Cohort-provided phenotype data to be used in Consortium-side and prioritized Consortium projects in DEFINE-T2D. This WG will inventory existing data, coordinate and prioritize harmonization efforts, establish and document harmonization best practices, and define consortium phenotype data standards.

Priorities:

• Across cohorts, identify and summarize important variables for diabetes identification (e.g., glucose), complications, and other related outcomes, in addition to any variables required for diabetes subtyping, including informed GWAS clustering
• Provide guidance on QC and harmonization of all variables above
• Provide guidance on the definition and harmonization of race, ethnicity and ancestry variables

Co-Conveners:

• Leslie Lange
• Shy Srinivasan

Members:

• Mike Bancks
• Alain Bertoni
• Kristen Boyle
• Zsu-Zsu Chen
• Dana Dabelea
• Eric Gamazon
• Mark Goodarzi
• Monique Hedderson
• Aaron Leong
• Josephine Li
• Peter Liu
• Kristen Nadeau
• Maggie Ng
• Mary Rooney
• Megan Shuey
• Kristina Utzschneider
• Xue Zhong

NIH Project Scientist:

• Norann Zaghloul

BRC Project Manager:

• Aastha Kakar

Scope:

Publications and Presentations (P&P) WG oversees the life cycle of Consortium papers from proposal development and approval to publication in scholarly journals and presentations at conferences.  As part of this process, the P&P WG will also provide guidance on authorship practices, and facilitate dissemination of findings to the scientific community and key stakeholders,

Priorities:

• Develop a process for project proposal and tracking.
• Develop tracking and review process for papers within the consortium, from concept/analysis proposal through publication. 
• Ensure appropriate utilization and interpretation of race, ethnicity and ancestry in products produced by the Consortium.
• Maintain list of established processes for publications & presentations that are specific to cohorts in the Consortium and develop a process tailored for the Consortium

Co-conveners:

• Mark Espeland
• Alisa Manning

Members :

• Anna Bellatorre
• Heidi Krause-Steinrauf
• Iain Konigsberg
• Maggie Ng
• Wei Perng
• Kristina Utzschneider
• Lynne Wagenknecht

NIH Project Scientist:

• Norann Zaghloul

BRC Project Manager:

• Kyle Salmon